Biomedical Science

Rigor and Reproducibility in Biomedical Research

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Guidelines and Resources

 

Effective January 25, 2016, NIH has established a formal initiative that requires most NIH and AHRQ research grant applications to comply with the NIH Policy on Rigor and Reproducibility.

For more information, see the official notice: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-16-011.html

This guide contains resources and tools that will help biomedical researchers to meet Rigor and Reproducibility Requirements from NIH. 

  • Federation of American Societies for Experimental Biology
    Enhancing Research Reproducibility is a collection of recommendations from FASEB that resulted from roundtable discussions. This document discusses overarching topics, mouse and other animal models, and antibodies
  • Global Biological Standards Institute (GBSI)
    GBSI is a non-profit organization dedicated to enhancing the quality of biomedical research by advocating best practices and standards to accelerate the translation of research breakthroughs into life-saving therapies.  GBSI has assembled some key publications.
  • American Physiological Society Science Policy Committee'sScientific Rigor and Reproducibility Toolbox
  • Neuronline- Resources to enhance Scientific rigor  in Neuroscience and Research Practices for scientific Rigor

Science Signaling

Statistics and Computational Analysis Specific for Biologists

Chemical Probes and Biomarkers

Resources for Considering Sex as a Biological Variable

Case Studies

Select a Repository for your Data/Supplemental Materials

  

Cell Line Authentication

NIH suggests "applicants proposing to use cell lines could describe the method they plan to use to verify the identity and purity of the lines, which might include short tandem repeat (STR) profiling and mycoplasma testing." Below are some resources for writing an authentication plan and procedures for authenticating cell lines.

Guidelines and Resources from Professional Organizations

Literature Review

Specific for Non-Human Cell Lines

Antibody Validation

Checklists and Validation Methods

Resources from Manufacturers

Literature Review

Image Guidelines

The following resources and guidelines are for researchers who acquire images and use software image like Photoshop.

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